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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   ATR Antibody (clone 1E9)   

ATR Antibody (clone 1E9)

Mouse Monoclonal Antibody

     
  • IHC - ATR Antibody (clone 1E9) ALS13280
    Anti-ATR antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q13535
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E9
Calculated MW 301kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 545
Other Names Serine/threonine-protein kinase ATR, 2.7.11.1, Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, ATR, FRP1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsATR Antibody (clone 1E9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATR
Synonyms FRP1
Function Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Cellular Location Nucleus. Nucleus, PML body {ECO:0000250|UniProtKB:Q9JKK8}. Chromosome {ECO:0000250|UniProtKB:Q9JKK8}. Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling
Tissue Location Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
Research Areas
Citations (0)

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Background

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

References

Bentley N.J.,et al.EMBO J. 15:6641-6651(1996).
Cimprich K.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:2850-2855(1996).
Mannino J.L.,et al.Gene 272:35-43(2001).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Keegan K.S.,et al.Genes Dev. 10:2423-2437(1996).

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$ 450.00
Cat# ALS13280
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