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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CBFA1 / RUNX2 Antibody (clone 1D8)   

CBFA1 / RUNX2 Antibody (clone 1D8)

Mouse Monoclonal Antibody

     
  • WB - CBFA1 / RUNX2 Antibody (clone 1D8) ALS13284
    RUNX2 monoclonal antibody, clone 1D8. Western blot of RUNX2 expression in SJCRH30.
  • WB - CBFA1 / RUNX2 Antibody (clone 1D8) ALS13284
    RUNX2 monoclonal antibody, clone 1D8 Western blot of RUNX2 expression in K-562.
  • IF - CBFA1 / RUNX2 Antibody (clone 1D8) ALS13284
    Immunofluorescence of monoclonal antibody to RUNX2 on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - CBFA1 / RUNX2 Antibody (clone 1D8) ALS13284
    Anti-RUNX2 antibody IHC of human prostate.
  • IHC - CBFA1 / RUNX2 Antibody (clone 1D8) ALS13284
    Anti-RUNX2 antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q13950
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1D8
Calculated MW 57kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 860
Other Names Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, CBF-alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, OSF-2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, RUNX2, AML3, CBFA1, OSF2, PEBP2A
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsCBFA1 / RUNX2 Antibody (clone 1D8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RUNX2
Synonyms AML3, CBFA1, OSF2, PEBP2A
Function Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Cellular Location Nucleus.
Tissue Location Specifically expressed in osteoblasts.
Research Areas
Citations (0)

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Background

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

References

Mundlos S.,et al.Cell 89:773-779(1997).
Geoffroy V.,et al.Mamm. Genome 9:54-57(1998).
Mungall A.J.,et al.Nature 425:805-811(2003).
Xiao Z.S.,et al.Gene 214:187-197(1998).
Zhang Y.-W.,et al.Oncogene 15:367-371(1997).

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$ 450.00
Cat# ALS13284
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