|Application ||WB, IHC-P, E|
|Dilution||IHC-P (2.5 µg/ml)|
|Other Names||Chloride intracellular channel protein 1, Chloride channel ABP, Nuclear chloride ion channel 27, NCC27, Regulatory nuclear chloride ion channel protein, hRNCC, CLIC1, G6, NCC27|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||CLIC1 / NCC27 Antibody (clone 2D4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.|
|Cellular Location||Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain|
|Tissue Location||Expression is prominent in heart, placenta, liver, kidney and pancreas.|
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Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Valenzuela S.M.,et al.J. Biol. Chem. 272:12575-12582(1997).
Noh Y.H.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Chuang J.Z.,et al.J. Neurosci. 19:2919-2928(1999).
Ribas G.,et al.J. Immunol. 163:278-287(1999).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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