|Application ||WB, IHC-P, IF, E, RNAi|
|Dilution||IF (10 µg/ml), IHC-P (5 µg/ml),|
|Other Names||Dual specificity protein phosphatase 6, 188.8.131.52, 184.108.40.206, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||MKP3 / DUSP6 Antibody (clone 3G2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Inactivates MAP kinases. Has a specificity for the ERK family.
Groom L.A.,et al.EMBO J. 15:3621-3632(1996).
Furukawa T.,et al.Cytogenet. Cell Genet. 82:156-159(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Stewart A.E.,et al.Nat. Struct. Biol. 6:174-181(1999).
Miraoui H.,et al.Am. J. Hum. Genet. 92:725-743(2013).
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