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MKP3 / DUSP6 Antibody (clone 3G2)

Mouse Monoclonal Antibody

     
  • WB - MKP3 / DUSP6 Antibody (clone 3G2) ALS13302
    Western blot of DUSP6 expression in transfected 293T cell line by DUSP6 monoclonal antibody,...
    detail
  • IF - MKP3 / DUSP6 Antibody (clone 3G2) ALS13302
    Immunofluorescence of monoclonal antibody to DUSP6 on HeLa cell (antibody concentration 10 ug/ml).
    detail
  • IHC - MKP3 / DUSP6 Antibody (clone 3G2) ALS13302
    Anti-DUSP6 antibody IHC of human heart.
    detail
  • IHC - MKP3 / DUSP6 Antibody (clone 3G2) ALS13302
    Anti-DUSP6 antibody IHC of human pancreas.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, RNAi
Primary Accession Q16828
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3G2
Calculated MW 42kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 1848
Other Names Dual specificity protein phosphatase 6, 3.1.3.16, 3.1.3.48, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsMKP3 / DUSP6 Antibody (clone 3G2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP6
Synonyms MKP3, PYST1
Function Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).
Cellular Location Cytoplasm.
Tissue Location Expressed in keratinocytes (at protein level).
Research Areas
Citations (0)
citation

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Background

Inactivates MAP kinases. Has a specificity for the ERK family.

References

Groom L.A.,et al.EMBO J. 15:3621-3632(1996).
Furukawa T.,et al.Cytogenet. Cell Genet. 82:156-159(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Stewart A.E.,et al.Nat. Struct. Biol. 6:174-181(1999).
Miraoui H.,et al.Am. J. Hum. Genet. 92:725-743(2013).

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Discontinued
Cat# ALS13302
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