|Application ||WB, IHC-P, IF, E|
|Dilution||IF (10 µg/ml), IHC-P (5 µg/ml),|
|Other Names||Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, 188.8.131.52, dUTP pyrophosphatase, DUT|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||DUT / DUTPase Antibody (clone 1C9) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.|
|Cellular Location||Isoform 2: Nucleus.|
|Tissue Location||Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Ladner R.D.,et al.J. Biol. Chem. 271:7745-7751(1996).
Cohen D.,et al.Genomics 40:213-215(1997).
Pearlman R.E.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Ladner R.D.,et al.J. Biol. Chem. 272:19072-19080(1997).
Chano T.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
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