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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   JUP/CTNNG/Junction Plakoglobin Antibody (clone 2G9)   

JUP/CTNNG/Junction Plakoglobin Antibody (clone 2G9)

Mouse Monoclonal Antibody

     
  • IF - JUP/CTNNG/Junction Plakoglobin Antibody (clone 2G9) ALS13349
    Immunofluorescence of monoclonal antibody to JUP on A-431 cell (antibody concentration 10 ug/ml).
  • IHC - JUP/CTNNG/Junction Plakoglobin Antibody (clone 2G9) ALS13349
    Anti-Gamma Catenin antibody IHC of human breast.
  • IHC - JUP/CTNNG/Junction Plakoglobin Antibody (clone 2G9) ALS13349
    Anti-Gamma Catenin antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P14923
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2G9
Calculated MW 82kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 3728
Other Names Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsJUP/CTNNG/Junction Plakoglobin Antibody (clone 2G9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JUP
Synonyms CTNNG, DP3
Function Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Cellular Location Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form
Research Areas
Citations (0)

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Background

Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

References

Franke W.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:4027-4031(1989).
Zimbelmann R.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Whittock N.V.,et al.Exp. Dermatol. 9:323-326(2000).
Liang X.-J.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 450.00
Cat# ALS13349
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