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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FKBP4 / FKBP52 Antibody (C-Terminus)   

FKBP4 / FKBP52 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - FKBP4 / FKBP52 Antibody (C-Terminus) ALS13363
    Antibody (0.01 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer).
  • IHC - FKBP4 / FKBP52 Antibody (C-Terminus) ALS13363
    Anti-FKBP52 antibody IHC of human brain, cerebellum.
  • IHC - FKBP4 / FKBP52 Antibody (C-Terminus) ALS13363
    Anti-FKBP52 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q02790
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 52kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.01-0.03 µg/ml)
Additional Information
Gene ID 2288
Other Names Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 5.2.1.8, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed, FKBP4, FKBP52
Target/Specificity Human FKBP4 / FKBP52.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsFKBP4 / FKBP52 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP4
Synonyms FKBP52
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Cellular Location Cytoplasm, cytosol. Mitochondrion. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity) {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.

References

Peattie D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:10974-10978(1992).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JAN-2010) to UniProtKB.
Tai P.-K.K.,et al.Science 256:1315-1318(1992).

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$ 395.00
Cat# ALS13363
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