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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AGAP2 / PIKE Antibody (Internal)   

AGAP2 / PIKE Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - AGAP2 / PIKE Antibody (Internal) ALS13368
    Antibody (0.3 ug/ml) staining of Human Amygdala lysate (35 ug protein in RIPA buffer).
  • IHC - AGAP2 / PIKE Antibody (Internal) ALS13368
    Anti-AGAP2 / PIKE antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q99490
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 125kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 116986
Other Names Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, AGAP-2, Centaurin-gamma-1, Cnt-g1, GTP-binding and GTPase-activating protein 2, GGAP2, Phosphatidylinositol 3-kinase enhancer, PIKE, AGAP2, CENTG1, KIAA0167
Target/Specificity Human AGAP2 / PIKE. This antibody is expected to recognize isoform PIKE-S (NP_055585.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAGAP2 / PIKE Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGAP2
Synonyms CENTG1, KIAA0167
Function GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Cellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Location Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart
Research Areas
Citations (0)

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Background

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

References

Elkahloun A.G.,et al.Genomics 42:295-301(1997).
Roe B.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Xia C.,et al.Mol. Cell. Biol. 23:2476-2488(2003).
Rong R.,et al.Nat. Neurosci. 6:1153-1161(2003).
Hong W.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13368
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