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OAS1 Antibody (clone 2D4)

Mouse Monoclonal Antibody

     
  • IHC - OAS1 Antibody (clone 2D4) ALS13369
    Anti-OAS1 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P00973
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2D4
Calculated MW 46kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4938
Other Names 2'-5'-oligoadenylate synthase 1, (2-5')oligo(A) synthase 1, 2-5A synthase 1, 2.7.7.84, E18/E16, p46/p42 OAS, OAS1, OIAS
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsOAS1 Antibody (clone 2D4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OAS1
Synonyms OIAS
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Cellular Location Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions
Citations (0)

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Background

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

References

Benech P.,et al.EMBO J. 4:2249-2256(1985).
Wathelet M.G.,et al.FEBS Lett. 196:113-120(1986).
Shiojiri S.,et al.J. Biochem. 99:1455-1464(1986).
Ghosh S.K.,et al.J. Biol. Chem. 266:15293-15299(1991).
Andersen J.B.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS13369
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