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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   HNRNP-E2 / PCBP2 Antibody (clone 5F12)   

HNRNP-E2 / PCBP2 Antibody (clone 5F12)

Mouse Monoclonal Antibody

     
  • WB - HNRNP-E2 / PCBP2 Antibody (clone 5F12) ALS13373
    Western blot of PCBP2 expression in transfected 293T cell line by PCBP2 monoclonal antibody...
  • WB - HNRNP-E2 / PCBP2 Antibody (clone 5F12) ALS13373
    PCBP2 monoclonal antibody clone 5F12 Western blot of PCBP2 expression in K-562.
  • IF - HNRNP-E2 / PCBP2 Antibody (clone 5F12) ALS13373
    Immunofluorescence of monoclonal antibody to PCBP2 on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - HNRNP-E2 / PCBP2 Antibody (clone 5F12) ALS13373
    Anti-PCBP2 antibody IHC of human testis.
  • IHC - HNRNP-E2 / PCBP2 Antibody (clone 5F12) ALS13373
    Anti-PCBP2 antibody IHC of human thyroid.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, RNAi
Primary Accession Q15366
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5F12
Calculated MW 39kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 5094
Other Names Poly(rC)-binding protein 2, Alpha-CP2, Heterogeneous nuclear ribonucleoprotein E2, hnRNP E2, PCBP2
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsHNRNP-E2 / PCBP2 Antibody (clone 5F12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCBP2
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).
Cellular Location Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm
Tissue Location Detected in all tissues examined.
Research Areas
Citations (0)

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Background

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.

References

Leffers H.,et al.Eur. J. Biochem. 230:447-453(1995).
Sugiyama A.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 450.00
Cat# ALS13373
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