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PTBP1 Antibody (clone 3H8)

Mouse Monoclonal Antibody

     
  • WB - PTBP1 Antibody (clone 3H8) ALS13379
    Western blot of PTBP1 expression in transfected 293T cell line by PTBP1 monoclonal antibody...
  • WB - PTBP1 Antibody (clone 3H8) ALS13379
    PTBP1 monoclonal antibody clone 3H8 Western blot of PTBP1 expression in A-431.
  • IF - PTBP1 Antibody (clone 3H8) ALS13379
    Immunofluorescence of monoclonal antibody to PTBP1 on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - PTBP1 Antibody (clone 3H8) ALS13379
    Anti-PTBP1 antibody IHC of human placenta.
  • IHC - PTBP1 Antibody (clone 3H8) ALS13379
    Anti-PTBP1 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P26599
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3H8
Calculated MW 57kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 5725
Other Names Polypyrimidine tract-binding protein 1, PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, PTBP1, PTB
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsPTBP1 Antibody (clone 3H8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTBP1
Synonyms PTB
Function Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).
Cellular Location Nucleus.
Citations (0)

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Background

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.

References

Gil A.,et al.Genes Dev. 5:1224-1236(1991).
Patton J.G.,et al.Genes Dev. 5:1237-1251(1991).
Ghetti A.,et al.Nucleic Acids Res. 20:3671-3678(1992).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).

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$ 450.00
Cat# ALS13379
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