|Application ||WB, IHC-P, E|
|Reactivity||Human, Hamster, Pig|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7|
|Target/Specificity||Human P2RX7 / P2X7.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||P2RX7 / P2X7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Widely expressed with highest levels in brain and immune tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Rassendren F.,et al.J. Biol. Chem. 272:5482-5486(1997).
Buell G.N.,et al.Recept. Channels 5:347-354(1998).
Cheewatrakoolpong B.,et al.Biochem. Biophys. Res. Commun. 332:17-27(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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