|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Small conductance calcium-activated potassium channel protein 2, SK2, SKCa 2, SKCa2, KCa2.2, KCNN2|
|Target/Specificity||Human KCNN2. This antibody is expected to recognize both isoforms (NP_067627.2; NP_740721.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||KCNN2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in atrial myocytes (at protein level). Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Desai R.,et al.J. Biol. Chem. 275:39954-39963(2000).
Xu Y.,et al.J. Biol. Chem. 278:49085-49094(2003).
Mazzone J.N.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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