|Application ||WB, IHC-P, E|
|Dilution||IHC-P (10-20 µg/ml)|
|Other Names||Rhotekin, RTKN (HGNC:10466), RTKN1|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||RTKN / Rhotekin Antibody (clone 2E5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.|
|Tissue Location||Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines|
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Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Fu Q.,et al.Genomics 66:328-332(2000).
Reynaud C.,et al.J. Biol. Chem. 275:33962-33968(2000).
Hillier L.W.,et al.Nature 434:724-731(2005).
Liu C.-A.,et al.Oncogene 23:8731-8742(2004).
Ito H.,et al.Oncogene 24:7064-7072(2005).
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