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TLN1 / Talin Antibody (clone 2E10)

Mouse Monoclonal Antibody

     
  • WB - TLN1 / Talin Antibody (clone 2E10) ALS13408
    TLN1 monoclonal antibody clone 2E10. Western blot of TLN1 expression in PC-12.
    detail
  • IHC - TLN1 / Talin Antibody (clone 2E10) ALS13408
    Anti-TLN1 / Talin antibody IHC of human testis.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y490
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 2E10
Calculated MW 270kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 7094
Other Names Talin-1, TLN1, KIAA1027, TLN
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTLN1 / Talin Antibody (clone 2E10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLN1
Synonyms KIAA1027, TLN
Function High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Involved in connections of major cytoskeletal structures to the plasma membrane (By similarity).
Cellular Location Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface {ECO:0000250|UniProtKB:P26039}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P26039}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).
Tissue Location [Isoform 2]: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression
Research Areas
Citations (0)
citation

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Background

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

References

Mao L.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Ben-Yosef T.,et al.Genomics 62:316-319(1999).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Humphray S.J.,et al.Nature 429:369-374(2004).

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Discontinued
Cat# ALS13408
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