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DKK3 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - DKK3 Antibody (C-Terminus) ALS13410
    Anti-DKK3 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UBP4
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 38kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (0.03-0.1 µg/ml)
Additional Information
Gene ID 27122
Other Names Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC
Target/Specificity Human DKK3. NP_037385.2; NP_056965.3 and NP_001018067.1 are varients of the same protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDKK3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKK3
Synonyms REIC
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Cellular Location Secreted.
Tissue Location Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}
Research Areas
Citations (0)

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Background

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

References

Krupnik V.E.,et al.Gene 238:301-313(1999).
Tsuji T.,et al.Biochem. Biophys. Res. Commun. 268:20-24(2000).
Kobayashi K.,et al.Gene 282:151-158(2002).
Tanaka S.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Tate G.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13410
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