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BCAP31 / BAP31 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - BCAP31 / BAP31 Antibody (C-Terminus) ALS13413
    BCAP31 antibody (0.1 ug/ml) staining of Human Breast lysate (35 ug protein/ml in RIPA buffer).
    detail
  • IHC - BCAP31 / BAP31 Antibody (C-Terminus) ALS13413
    Anti-BCAP31 / BAP31 antibody IHC of human brain, cerebellum.
    detail
  • IHC - BCAP31 / BAP31 Antibody (C-Terminus) ALS13413
    Anti-BCAP31 / BAP31 antibody IHC of human brain, cortex.
    detail
  • IHC - BCAP31 / BAP31 Antibody (C-Terminus) ALS13413
    Anti-BCAP31 / BAP31 antibody IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P51572
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 28kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 10134
Other Names B-cell receptor-associated protein 31, BCR-associated protein 31, Bap31, 6C6-AG tumor-associated antigen, Protein CDM, p28, BCAP31, BAP31, DXS1357E
Target/Specificity Human BCAP31 / BAP31. This antibody is expected to recognise isoform a (NP_001132929.1) and isoform b (NP_005736.3; NP_001132913.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsBCAP31 / BAP31 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCAP31 (HGNC:16695)
Function Functions as a chaperone protein (PubMed:9396746, PubMed:18287538). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746). Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022)
Tissue Location Ubiquitous. Highly expressed in neurons and discrete endocrine cells.
Research Areas
Citations (0)
citation

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Background

Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis.

References

Mosser J.,et al.Genomics 22:469-471(1994).
Li E.,et al.Eur. J. Biochem. 238:631-638(1996).
Adachi T.,et al.EMBO J. 15:1534-1541(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).

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Discontinued
Cat# ALS13413
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