|Application ||IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml),|
|Other Names||Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM|
|Target/Specificity||Human CCNDBP1 / GCIP. This antibody is expected to recognise both human isoforms of this protein.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CCNDBP1 / GCIP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DIP1, GCIP, HHM|
|Function||May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.|
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May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription.
Yao Y.,et al.Exp. Cell Res. 257:22-32(2000).
Terai S.,et al.Hepatology 32:357-366(2000).
Xia C.,et al.J. Biol. Chem. 275:20942-20948(2000).
Gao J.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
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