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STXBP1 / MUNC18-1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - STXBP1 / MUNC18-1 Antibody (C-Terminus) ALS13421
    Anti-STXBP1 antibody IHC of human brain, cortex.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P61764
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 68kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml)
Additional Information
Gene ID 6812
Other Names Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A
Target/Specificity Human STXBP1. This antibody is expected to recognize isoform a (NP_003156.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSTXBP1 / MUNC18-1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STXBP1
Synonyms UNC18A
Function Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions.
Cellular Location Cytoplasm, cytosol. Membrane; Peripheral membrane protein
Tissue Location Brain and spinal cord. Highly enriched in axons.
Research Areas
Citations (0)
citation

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Background

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

References

Gengyo-Ando K.,et al.J. Neurosci. 16:6695-6702(1996).
Swanson D.A.,et al.Genomics 48:373-376(1998).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tian J.H.,et al.J. Biol. Chem. 278:26265-26274(2003).

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Discontinued
Cat# ALS13421
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