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Vitamin D Receptor / VDR Antibody (clone 2F4)

Mouse Monoclonal Antibody

     
  • IHC - Vitamin D Receptor / VDR Antibody (clone 2F4) ALS13424
    Anti-VDR antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P11473
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F4
Calculated MW 48kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 7421
Other Names Vitamin D3 receptor, VDR, 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsVitamin D Receptor / VDR Antibody (clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VDR
Synonyms NR1I1
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

References

Baker A.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
Goto H.,et al.Biochim. Biophys. Acta 1132:103-108(1992).
Rae J.L.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Miyamoto K.,et al.Mol. Endocrinol. 11:1165-1179(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 450.00
Cat# ALS13424
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