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CTNNA1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P35221 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Chicken, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 100kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 1495 |
|---|---|
| Other Names | Catenin alpha-1, Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13, CTNNA1 |
| Target/Specificity | Human CTNNA1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CTNNA1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTNNA1 |
|---|---|
| Function | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1- dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. |
| Cellular Location | [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries |
| Tissue Location | Expressed ubiquitously in normal tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
References
Furukawa Y.,et al.Cytogenet. Cell Genet. 65:74-78(1994).
Oda T.,et al.Biochem. Biophys. Res. Commun. 193:897-904(1993).
Rimm D.L.,et al.Biochem. Biophys. Res. Commun. 203:1691-1699(1994).
Kask M.,et al.Biochem. Biophys. Res. Commun. 411:56-61(2011).
Nollet F.H.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
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