|Application ||WB, IHC-P, E|
|Reactivity||Human, Rabbit, Horse, Dog|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.2-0.6 µg/ml)|
|Other Names||1-acylglycerol-3-phosphate O-acyltransferase ABHD5, 18.104.22.168, Abhydrolase domain-containing protein 5, Lipid droplet-binding protein CGI-58, ABHD5, NCIE2|
|Target/Specificity||Human ABHD5 / CGI-58. This antibody is not expected to cross-react with ABHD4.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ABHD5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity).|
|Cellular Location||Cytoplasm. Lipid droplet. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).|
|Tissue Location||Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.
Lefevre C.,et al.Am. J. Hum. Genet. 69:1002-1012(2001).
Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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