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>   home   >   Products   >   Primary Antibodies   >   KHSRP / KSRP Antibody (clone 4C10)   

KHSRP / KSRP Antibody (clone 4C10)

Mouse Monoclonal Antibody

     
  • IHC - KHSRP / KSRP Antibody (clone 4C10) ALS13443
    Anti-KHSRP antibody IHC of human testis.
  • IHC - KHSRP / KSRP Antibody (clone 4C10) ALS13443
    Anti-KHSRP antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q92945
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4C10
Calculated MW 73kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 8570
Other Names Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsKHSRP / KSRP Antibody (clone 4C10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KHSRP
Synonyms FUBP2
Function Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs.
Cellular Location Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.
Tissue Location Detected in neural and non-neural cell lines.
Citations (0)

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Background

Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs.

References

Min H.,et al.Genes Dev. 11:1023-1036(1997).
Grimwood J.,et al.Nature 428:529-535(2004).
Ring H.Z.,et al.Genomics 56:350-352(1999).
Davis-Smyth T.,et al.J. Biol. Chem. 271:31679-31687(1996).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 450.00
Cat# ALS13443
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