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CYTH1 / Cytohesin-1 Antibody (clone 1D6)

Mouse Monoclonal Antibody

     
  • IF - CYTH1 / Cytohesin-1 Antibody (clone 1D6) ALS13452
    Immunofluorescence of monoclonal antibody to PSCD1 on HeLa cell (antibody concentration 10 ug/ml).
    detail
  • IHC - CYTH1 / Cytohesin-1 Antibody (clone 1D6) ALS13452
    Anti-CYTH1 antibody IHC of human placenta.
    detail
  • IHC - CYTH1 / Cytohesin-1 Antibody (clone 1D6) ALS13452
    Anti-CYTH1 antibody IHC of human tonsil.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q15438
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1D6
Calculated MW 46kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 9267
Other Names Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1, CYTH1, D17S811E, PSCD1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsCYTH1 / Cytohesin-1 Antibody (clone 1D6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYTH1 (HGNC:9501)
Synonyms D17S811E, PSCD1
Function Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
Cellular Location Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250|UniProtKB:Q9QX11}
Tissue Location Ubiquitous.
Research Areas
Citations (0)
citation

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Background

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

References

Liu L.,et al.Biochim. Biophys. Acta 1132:75-78(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Ogasawara M.,et al.J. Biol. Chem. 275:3221-3230(2000).
Vitale N.,et al.J. Biol. Chem. 275:21331-21339(2000).

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Discontinued
Cat# ALS13452
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