CYTH1 / Cytohesin-1 Antibody (clone 1D6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | Q15438 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1D6 |
Calculated MW | 46kDa |
Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 9267 |
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Other Names | Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1, CYTH1, D17S811E, PSCD1 |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | CYTH1 / Cytohesin-1 Antibody (clone 1D6) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CYTH1 (HGNC:9501) |
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Synonyms | D17S811E, PSCD1 |
Function | Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. |
Cellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250|UniProtKB:Q9QX11} |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
References
Liu L.,et al.Biochim. Biophys. Acta 1132:75-78(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Ogasawara M.,et al.J. Biol. Chem. 275:3221-3230(2000).
Vitale N.,et al.J. Biol. Chem. 275:21331-21339(2000).
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