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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SH3BP5 / SAB Antibody (clone 2B3)   

SH3BP5 / SAB Antibody (clone 2B3)

Mouse Monoclonal Antibody

     
  • WB - SH3BP5 / SAB Antibody (clone 2B3) ALS13453
    SH3BP5 monoclonal antibody (M01), clone 2B3 Western blot of SH3BP5 expression in A-431.
  • IF - SH3BP5 / SAB Antibody (clone 2B3) ALS13453
    Immunofluorescence of monoclonal antibody to SH3BP5 on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - SH3BP5 / SAB Antibody (clone 2B3) ALS13453
    Anti-SH3BP5 antibody IHC of human adrenal.
  • IHC - SH3BP5 / SAB Antibody (clone 2B3) ALS13453
    Anti-SH3BP5 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O60239
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2B3
Calculated MW 50kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 9467
Other Names SH3 domain-binding protein 5, SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SH3BP5, SAB
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsSH3BP5 / SAB Antibody (clone 2B3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3BP5
Synonyms SAB
Function Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Cellular Location Mitochondrion.
Tissue Location Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
Research Areas
Citations (0)

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Background

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

References

Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Matsushita M.,et al.Biochem. Biophys. Res. Commun. 245:337-343(1998).

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$ 450.00
Cat# ALS13453
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