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SH3BP5 / SAB Antibody (clone 2B3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | O60239 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2B3 |
| Calculated MW | 50kDa |
| Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), |
| Gene ID | 9467 |
|---|---|
| Other Names | SH3 domain-binding protein 5, SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SH3BP5, SAB |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | SH3BP5 / SAB Antibody (clone 2B3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SH3BP5 |
|---|---|
| Synonyms | SAB |
| Function | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B- cells. May be involved in BCR-induced apoptotic cell death. |
| Cellular Location | Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. |
| Tissue Location | Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
References
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Matsushita M.,et al.Biochem. Biophys. Res. Commun. 245:337-343(1998).
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