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RBM5 / G15 Antibody (clone 2B6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, RNAi |
|---|---|
| Primary Accession | P52756 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2B6 |
| Calculated MW | 92kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 10181 |
|---|---|
| Other Names | RNA-binding protein 5, Protein G15, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, Renal carcinoma antigen NY-REN-9, RBM5 |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | RBM5 / G15 Antibody (clone 2B6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBM5 |
|---|---|
| Function | Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. |
| Cellular Location | Nucleus. |
| Tissue Location | Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
References
Bader S.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
Timmer T.,et al.Genomics 60:238-240(1999).
Oh J.J.,et al.Nucleic Acids Res. 27:4008-4017(1999).
Oh J.J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Sutherland L.C.,et al.Oncogene 19:3774-3781(2000).
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