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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   RBM5 / G15 Antibody (clone 2B6)   

RBM5 / G15 Antibody (clone 2B6)

Mouse Monoclonal Antibody

     
  • IHC - RBM5 / G15 Antibody (clone 2B6) ALS13460
    Anti-RBM5 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, RNAi
Primary Accession P52756
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2B6
Calculated MW 92kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 10181
Other Names RNA-binding protein 5, Protein G15, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, Renal carcinoma antigen NY-REN-9, RBM5
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsRBM5 / G15 Antibody (clone 2B6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBM5
Function Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Cellular Location Nucleus.
Tissue Location Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines
Research Areas
Citations (0)

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Background

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

References

Bader S.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
Timmer T.,et al.Genomics 60:238-240(1999).
Oh J.J.,et al.Nucleic Acids Res. 27:4008-4017(1999).
Oh J.J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Sutherland L.C.,et al.Oncogene 19:3774-3781(2000).

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$ 450.00
Cat# ALS13460
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