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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TOPORS Antibody (clone 5G11)   

TOPORS Antibody (clone 5G11)

Mouse Monoclonal Antibody

     
  • WB - TOPORS Antibody (clone 5G11) ALS13461
    TOPORS monoclonal antibody clone 5G11 Western blot of TOPORS expression in HeLa NE.
  • IF - TOPORS Antibody (clone 5G11) ALS13461
    Immunofluorescence of monoclonal antibody to TOPORS on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - TOPORS Antibody (clone 5G11) ALS13461
    Anti-TOPORS antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9NS56
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5G11
Calculated MW 119kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 10210
Other Names E3 ubiquitin-protein ligase Topors, 6.3.2.-, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, p53-binding protein 3, p53BP3, TOPORS, LUN, TP53BPL
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTOPORS Antibody (clone 5G11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOPORS
Synonyms LUN, TP53BPL
Function Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation.
Cellular Location Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage
Tissue Location Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.
Research Areas
Citations (0)

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Background

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation.

References

Haluska P. Jr.,et al.Nucleic Acids Res. 27:2538-2544(1999).
Chu D.,et al.J. Biol. Chem. 276:14004-14013(2001).
Humphray S.J.,et al.Nature 429:369-374(2004).
Zhou R.,et al.Gene 235:93-101(1999).
Rasheed Z.A.,et al.Exp. Cell Res. 277:152-160(2002).

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$ 450.00
Cat# ALS13461
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