|Application ||WB, IHC-P, IHC-Fr, Flo|
|Dilution||IHC-Fr, IHC-P (20 µg/ml), WB (2 µg/ml)|
|Other Names||ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 188.8.131.52, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 184.108.40.206, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38, CD38|
|Target/Specificity||Reacts with CD38 (T10), a 45 kD type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CD38 Antibody (clone HIT2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.|
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Provided below are standard protocols that you may find useful for product applications.
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Jackson D.G.,et al.J. Immunol. 144:2811-2815(1990).
Nata K.,et al.Gene 186:285-292(1997).
States D.J.,et al.Trends Biochem. Sci. 17:495-495(1992).
Takasawa S.,et al.J. Biol. Chem. 268:26052-26054(1993).
Tohgo A.,et al.J. Biol. Chem. 269:28555-28557(1994).
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