|Application ||WB, IHC-P, ICC, IP|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Leukocyte-specific transcript 1 protein, Protein B144, LST1, B144|
|Target/Specificity||The antibody LST1/02 reacts with an extracellular epitope of LST1, an approximately 6-11 kD protein expressed as various transmembrane or soluble forms. LST1 is found predominantly on monocytes and dendritic cells. It migrates on SDS PAGE gels as app ...|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||LST1 Antibody (clone LST1/02) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.|
|Cellular Location||Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm|
|Tissue Location||Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain|
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Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Holzinger I.,et al.Immunogenetics 42:315-322(1995).
de Baey A.,et al.Genomics 45:591-600(1997).
Rollinger-Holzinger I.,et al.J. Immunol. 164:3169-3176(2000).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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