|Application ||WB, IHC-P, ICC, IHC-Fr|
|Dilution||IHC-Fr (1 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml)|
|Other Names||Anterior gradient protein 3 homolog, AG-3, AG3, hAG-3, Breast cancer membrane protein 11, AGR3, BCMP11|
|Target/Specificity||The antibody AGR3.1 recognizes the epitope HETTDKNLS within the AGR3 (AG3) protein (19-20 kD); a secreted cytoplasmic protein which can serve as a marker of carcinogenesis.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||AG3 / AGR3 Antibody (clone AGR3.1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.|
|Cellular Location||Endoplasmic reticulum Note=Found in the cytoplasm, which could include the endoplasmic reticulum.|
|Tissue Location||Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668) Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690) Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690)|
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Provided below are standard protocols that you may find useful for product applications.
Adam P.J.,et al.J. Biol. Chem. 278:6482-6489(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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