|Application ||IHC-P, Flo|
|Dilution||Flo (1.5-2.5 µg/ml), IHC-P (10 µg/ml),|
|Other Names||P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG|
|Target/Specificity||The antibody TC2 reacts with CD162, a 220 kD type I integral membrane protein expressed as disulfide-linked homodimer (sialomucin family). CD162 is present on the most peripheral blood T lymphocytes, monocytes, granulocytes; it is also expressed on a ...|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||SELPLG / PSGL-1 / CD162 Antibody (clone TC2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on neutrophils, monocytes and most lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
Veldman G.M.,et al.J. Biol. Chem. 270:16470-16475(1995).
Sako D.,et al.Cell 75:1179-1186(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Moore K.L.,et al.J. Biol. Chem. 269:23318-23327(1994).
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