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SELPLG / PSGL-1 / CD162 Antibody (clone TC2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, Flo |
|---|---|
| Primary Accession | Q14242 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | TC2 |
| Calculated MW | 43kDa |
| Dilution | Flo (1.5-2.5 µg/ml), IHC-P (10 µg/ml), |
| Gene ID | 6404 |
|---|---|
| Other Names | P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG |
| Target/Specificity | The antibody TC2 reacts with CD162, a 220 kD type I integral membrane protein expressed as disulfide-linked homodimer (sialomucin family). CD162 is present on the most peripheral blood T lymphocytes, monocytes, granulocytes; it is also expressed on a ... |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | SELPLG / PSGL-1 / CD162 Antibody (clone TC2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SELPLG |
|---|---|
| Function | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expressed on neutrophils, monocytes and most lymphocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
References
Veldman G.M.,et al.J. Biol. Chem. 270:16470-16475(1995).
Sako D.,et al.Cell 75:1179-1186(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Moore K.L.,et al.J. Biol. Chem. 269:23318-23327(1994).
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