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>   home   >   Products   >   Primary Antibodies   >   GPN1 / XAB1 Antibody (clone 3E1)   

GPN1 / XAB1 Antibody (clone 3E1)

Mouse Monoclonal Antibody

     
  • WB - GPN1 / XAB1 Antibody (clone 3E1) ALS13480
    XAB1 monoclonal antibody clone 3E1 Western blot of XAB1 expression in HL-60.
  • WB - GPN1 / XAB1 Antibody (clone 3E1) ALS13480
    Western blot of XAB1 expression in transfected 293T cell line by XAB1 monoclonal antibody, clone...
  • IF - GPN1 / XAB1 Antibody (clone 3E1) ALS13480
    Immunofluorescence of monoclonal antibody to XAB1 on HeLa cell (antibody concentration 10 ug/ml).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9HCN4
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3E1
Calculated MW 42kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 11321
Other Names GPN-loop GTPase 1, 3.6.5.-, MBD2-interacting protein, MBDin, RNAPII-associated protein 4, XPA-binding protein 1, GPN1 {ECO:0000303|PubMed:20855544, ECO:0000312|HGNC:HGNC:17030}
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsGPN1 / XAB1 Antibody (clone 3E1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPN1 {ECO:0000303|PubMed:20855544, ECO:0000312|HGNC:HGNC:17030}
Function Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Location Expressed ubiquitously.
Citations (0)

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Background

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).

References

Nitta M.,et al.Nucleic Acids Res. 28:4212-4218(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bienvenut W.V.,et al.Submitted (MAR-2009) to UniProtKB.
Stanchi F.,et al.Yeast 18:69-80(2001).

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$ 450.00
Cat# ALS13480
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