GPN1 / XAB1 Antibody (clone 3E1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9HCN4 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3E1 |
Calculated MW | 42kDa |
Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), |
Gene ID | 11321 |
---|---|
Other Names | GPN-loop GTPase 1, 3.6.5.-, MBD2-interacting protein, MBDin, RNAPII-associated protein 4, XPA-binding protein 1, GPN1 {ECO:0000303|PubMed:20855544, ECO:0000312|HGNC:HGNC:17030} |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | GPN1 / XAB1 Antibody (clone 3E1) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPN1 {ECO:0000303|PubMed:20855544, ECO:0000312|HGNC:HGNC:17030} |
---|---|
Function | Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). |
Cellular Location | Cytoplasm. Nucleus Note=Shuttles between the nucleus and the cytoplasm |
Tissue Location | Expressed ubiquitously. |
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Background
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).
References
Nitta M.,et al.Nucleic Acids Res. 28:4212-4218(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Bienvenut W.V.,et al.Submitted (MAR-2009) to UniProtKB.
Stanchi F.,et al.Yeast 18:69-80(2001).
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