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TDP-43 / TARDBP Antibody (clone 2E2-D3)

Mouse Monoclonal Antibody

     
  • WB - TDP-43 / TARDBP Antibody (clone 2E2-D3) ALS13483
    TARDBP monoclonal antibody clone 2E2-D3 Western blot of TARDBP expression in A-431.
  • IF - TDP-43 / TARDBP Antibody (clone 2E2-D3) ALS13483
    Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - TDP-43 / TARDBP Antibody (clone 2E2-D3) ALS13483
    Anti-TARDBP antibody IHC of human brain, cortex.
  • IHC - TDP-43 / TARDBP Antibody (clone 2E2-D3) ALS13483
    Anti-TARDBP antibody IHC of human kidney.
  • IHC - TDP-43 / TARDBP Antibody (clone 2E2-D3) ALS13483
    Anti-TARDBP antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, RNAi
Primary Accession Q13148
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E2-D3
Calculated MW 45kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 23435
Other Names TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTDP-43 / TARDBP Antibody (clone 2E2-D3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TARDBP
Synonyms TDP43
Function DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Cellular Location Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies
Tissue Location Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen
Research Areas
Citations (0)

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Background

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

References

Ou S.-H.I.,et al.J. Virol. 69:3584-3596(1995).
Strong M.J.,et al.Mol. Cell. Neurosci. 35:320-327(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS13483
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