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ATP6V1D / V-ATPase subunit D Antibody (clone 3G4)

Mouse Monoclonal Antibody

     
  • IHC - ATP6V1D / V-ATPase subunit D Antibody (clone 3G4) ALS13488
    Anti-ATP6V1D antibody IHC of human heart.
    detail
  • IHC - ATP6V1D / V-ATPase subunit D Antibody (clone 3G4) ALS13488
    Anti-ATP6V1D antibody IHC of human placenta.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y5K8
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3G4
Calculated MW 28kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 51382
Other Names V-type proton ATPase subunit D, V-ATPase subunit D, V-ATPase 28 kDa accessory protein, Vacuolar proton pump subunit D, ATP6V1D, ATP6M, VATD
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsATP6V1D / V-ATPase subunit D Antibody (clone 3G4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP6V1D
Synonyms ATP6M, VATD
Function Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891).
Cellular Location Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle membrane {ECO:0000250|UniProtKB:P39942}; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localizes to centrosome and the base of the cilium.
Research Areas
Citations (0)
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Background

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.

References

Zhao Y.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Quan L.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS13488
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