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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EDEM2 Antibody (clone 2E4)   

EDEM2 Antibody (clone 2E4)

Mouse Monoclonal Antibody

     
  • IHC - EDEM2 Antibody (clone 2E4) ALS13491
    Anti-EDEM2 / C20orf31 antibody IHC of human heart.
  • IHC - EDEM2 Antibody (clone 2E4) ALS13491
    Anti-EDEM2 / C20orf31 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BV94
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E4
Calculated MW 65kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 55741
Other Names ER degradation-enhancing alpha-mannosidase-like protein 2, EDEM2, C20orf31, C20orf49
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsEDEM2 Antibody (clone 2E4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EDEM2
Synonyms C20orf31, C20orf49
Function Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Cellular Location Endoplasmic reticulum lumen
Tissue Location Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
Research Areas
Citations (0)

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Background

Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS13491
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