|Application ||WB, IHC-P, IF, E|
|Dilution||IF (10 µg/ml), IHC-P (10 µg/ml),|
|Other Names||Serine/threonine-protein kinase 33, 126.96.36.199, STK33|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||STK33 Antibody (clone 3F10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.|
|Cellular Location||Cytoplasm, perinuclear region.|
|Tissue Location||Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.
Mujica A.O.,et al.Gene 280:175-181(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mujica A.O.,et al.FEBS J. 272:4884-4898(2005).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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