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THOC6 Antibody (clone 1F6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q86W42 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1F6 |
| Calculated MW | 38kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 79228 |
|---|---|
| Other Names | THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, fSAP35, WD repeat-containing protein 58, THOC6, WDR58 |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | THOC6 Antibody (clone 1F6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THOC6 |
|---|---|
| Synonyms | WDR58 |
| Function | Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. |
| Cellular Location | Nucleus. Nucleus speckle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Guo S.,et al.Cancer Res. 65:3011-3016(2005).
Masuda S.,et al.Genes Dev. 19:1512-1517(2005).
Cheng H.,et al.Cell 127:1389-1400(2006).
Boyne J.R.,et al.PLoS Pathog. 4:E1000194-E1000194(2008).
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