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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   THOC6 Antibody (clone 1F6)   

THOC6 Antibody (clone 1F6)

Mouse Monoclonal Antibody

     
  • WB - THOC6 Antibody (clone 1F6) ALS13497
    WDR58 monoclonal antibody, clone 1F6. Western blot of WDR58 expression in PC-12.
  • WB - THOC6 Antibody (clone 1F6) ALS13497
    WDR58 monoclonal antibody, clone 1F6 Western blot of WDR58 expression in A-431.
  • IHC - THOC6 Antibody (clone 1F6) ALS13497
    Anti-THOC6 / WDR58 antibody IHC of human colon.
  • IHC - THOC6 Antibody (clone 1F6) ALS13497
    Anti-THOC6 / WDR58 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q86W42
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Clone Names 1F6
Calculated MW 38kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 79228
Other Names THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, fSAP35, WD repeat-containing protein 58, THOC6, WDR58
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTHOC6 Antibody (clone 1F6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THOC6
Synonyms WDR58
Function Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
Cellular Location Nucleus. Nucleus speckle
Research Areas
Citations (0)

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Background

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Guo S.,et al.Cancer Res. 65:3011-3016(2005).
Masuda S.,et al.Genes Dev. 19:1512-1517(2005).
Cheng H.,et al.Cell 127:1389-1400(2006).
Boyne J.R.,et al.PLoS Pathog. 4:E1000194-E1000194(2008).

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$ 450.00
Cat# ALS13497
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