SPSB2 Antibody (clone 1E6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q99619 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1E6 |
Calculated MW | 29kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 84727 |
---|---|
Other Names | SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9, SPSB2, GRCC9, SSB2 |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | SPSB2 Antibody (clone 1E6) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SPSB2 |
---|---|
Synonyms | GRCC9, SSB2 |
Function | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). |
Cellular Location | Cytoplasm. Cytoplasm, cytosol. Note=Exhibits a diffuse cytosolic localization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
References
Friedel E.J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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