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SPSB2 Antibody (clone 1E6)

Mouse Monoclonal Antibody

     
  • WB - SPSB2 Antibody (clone 1E6) ALS13501
    GRCC9 monoclonal antibody, clone 1E6 Western blot of SPSB2 expression in A-549.
    detail
  • IHC - SPSB2 Antibody (clone 1E6) ALS13501
    Anti-SPSB2 antibody IHC of human small intestine.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q99619
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E6
Calculated MW 29kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 84727
Other Names SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9, SPSB2, GRCC9, SSB2
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsSPSB2 Antibody (clone 1E6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPSB2
Synonyms GRCC9, SSB2
Function Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).
Cellular Location Cytoplasm. Cytoplasm, cytosol. Note=Exhibits a diffuse cytosolic localization.
Research Areas
Citations (0)
citation

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Background

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

References

Friedel E.J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS13501
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