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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PRPK / TP53RK Antibody (clone 4B9-1H3)   

PRPK / TP53RK Antibody (clone 4B9-1H3)

Mouse Monoclonal Antibody

     
  • IHC - PRPK / TP53RK Antibody (clone 4B9-1H3) ALS13503
    Anti-TP53RK antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96S44
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4B9-1H3
Calculated MW 28kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 112858
Other Names TP53-regulating kinase, 2.7.11.1, Atypical serine/threonine protein kinase TP53RK, EKC/KEOPS complex subunit TP53RK, 3.6.-.-, Nori-2, p53-related protein kinase, TP53RK, C20orf64, PRPK
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsPRPK / TP53RK Antibody (clone 4B9-1H3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53RK
Synonyms C20orf64, PRPK
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Cellular Location Nucleus.
Tissue Location Highly expressed in testis. Weakly expressed in heart kidney and spleen
Research Areas
Citations (0)

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Background

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.

References

Abe Y.,et al.J. Biol. Chem. 276:44003-44011(2001).
Abe Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS13503
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