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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RNF144B Antibody (clone 4F1)   

RNF144B Antibody (clone 4F1)

Mouse Monoclonal Antibody

     
  • WB - RNF144B Antibody (clone 4F1) ALS13509
    RNF144B monoclonal antibody, clone 4F1 Western blot of IBRDC2 expression in IMR-32.
  • IF - RNF144B Antibody (clone 4F1) ALS13509
    Immunofluorescence of monoclonal antibody to IBRDC2 on HeLa cell (antibody concentration 10 ug/ml).
  • IHC - RNF144B Antibody (clone 4F1) ALS13509
    Anti-RNF144B antibody IHC of human kidney.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7Z419
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4F1
Calculated MW 34kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 255488
Other Names E3 ubiquitin-protein ligase RNF144B, 6.3.2.-, IBR domain-containing protein 2, RING finger protein 144B, p53-inducible RING finger protein, RNF144B, IBRDC2, P53RFP
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsRNF144B Antibody (clone 4F1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF144B
Synonyms IBRDC2, P53RFP
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Cellular Location Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation
Tissue Location Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
Research Areas
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Background

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

References

Ng C.-C.,et al.Oncogene 22:4449-4458(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS13509
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