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FNIP2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

  • WB - FNIP2 Antibody (C-Terminus) ALS13522
    Western blot of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 ug/ml.
  • IHC - FNIP2 Antibody (C-Terminus) ALS13522
    Anti-FNIP2 antibody IHC of human colon, submucosal plexus.
  • IHC - FNIP2 Antibody (C-Terminus) ALS13522
    Anti-FNIP2 antibody IHC of human placenta.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P278
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 122kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 57600
Other Names Folliculin-interacting protein 2, FNIP1-like protein, O6-methylguanine-induced apoptosis 1 protein, FNIP2, FNIPL, KIAA1450, MAPO1
Target/Specificity Human FNIP2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsFNIP2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FNIP2
Synonyms FNIPL, KIAA1450, MAPO1
Function Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:18403135). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).
Cellular Location Cytoplasm Note=Colocalizes with FLCN in the cytoplasm
Tissue Location Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue (PubMed:18403135). Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue (PubMed:27353360).
Research Areas
Citations (0)

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May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.


Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hasumi H.,et al.Gene 415:60-67(2008).
Takagi Y.,et al.Oncogene 27:5339-5347(2008).
Komori K.,et al.Oncogene 28:1142-1150(2009).

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$ 395.00
Cat# ALS13522
Availability: 5 days
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