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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FNIP2 Antibody (C-Terminus)   

FNIP2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - FNIP2 Antibody (C-Terminus) ALS13522
    Western blot of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • IHC - FNIP2 Antibody (C-Terminus) ALS13522
    Anti-FNIP2 antibody IHC of human colon, submucosal plexus.
    detail
  • IHC - FNIP2 Antibody (C-Terminus) ALS13522
    Anti-FNIP2 antibody IHC of human placenta.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9P278
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 122kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 57600
Other Names Folliculin-interacting protein 2, FNIP1-like protein, O6-methylguanine-induced apoptosis 1 protein, FNIP2, FNIPL, KIAA1450, MAPO1
Target/Specificity Human FNIP2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsFNIP2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FNIP2 {ECO:0000303|PubMed:18663353, ECO:0000312|HGNC:HGNC:29280}
Function Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913, PubMed:36103527). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non- canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913, PubMed:36103527). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase- activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity).
Cellular Location Lysosome membrane. Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.
Tissue Location Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas (PubMed:18403135, PubMed:18663353, PubMed:27353360) Moderately expressed in the lung, small intestine, kidney and brain Lower levels detected in renal cell carcinoma than in normal kidney tissue (PubMed:18403135). Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue (PubMed:27353360)
Research Areas
Citations (0)
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Background

May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

References

Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hasumi H.,et al.Gene 415:60-67(2008).
Takagi Y.,et al.Oncogene 27:5339-5347(2008).
Komori K.,et al.Oncogene 28:1142-1150(2009).

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Discontinued
Cat# ALS13522
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