TMEM16B / ANO2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9NQ90 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 114kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 57101 |
---|---|
Other Names | Anoctamin-2, Transmembrane protein 16B, ANO2, C12orf3, TMEM16B |
Target/Specificity | Human ANO2 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | TMEM16B / ANO2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANO2 |
---|---|
Synonyms | C12orf3, TMEM16B |
Function | Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Retina, especially in the photoreceptor synaptic terminals. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
References
Lorenz B.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Stoehr H.,et al.J. Neurosci. 29:6809-6818(2009).
Scherer S.E.,et al.Nature 440:346-351(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schreiber R.,et al.J. Biol. Chem. 285:7838-7845(2010).
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