DPPL1 / PPAPDC1B Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q8NEB5 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 29kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 84513 |
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Other Names | Phosphatidate phosphatase PPAPDC1B, 3.1.3.4, Phosphatidic acid phosphatase type 2 domain-containing protein 1B, PPAPDC1B, DPPL1, HTPAP |
Target/Specificity | Human PPAPDC1B |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | DPPL1 / PPAPDC1B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLPP5 (HGNC:25026) |
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Function | Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538). |
Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q3UMZ3} |
Tissue Location | Ubiquitous.. |
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Background
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
References
Takeuchi M.,et al.Gene 399:174-180(2007).
Nusbaum C.,et al.Nature 439:331-335(2006).
Li Y.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.Oncogene 25:1832-1840(2006).
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