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DCLK2 / DCAMKL2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - DCLK2 / DCAMKL2 Antibody (C-Terminus) ALS13557
    Western blot analysis of DCLK2 in rat brain tissue lysate with DCLK2 antibody at (A) 1 and (B) 2...
  • IHC - DCLK2 / DCAMKL2 Antibody (C-Terminus) ALS13557
    Anti-DCLK2 / DCAMKL2 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8N568
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 84kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 166614
Other Names Serine/threonine-protein kinase DCLK2, 2.7.11.1, CaMK-like CREB regulatory kinase 2, CL2, CLICK-II, CLICK2, Doublecortin domain-containing protein 3B, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2, DCLK2, DCAMKL2, DCDC3B, DCK2
Target/Specificity Human DCLK2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsDCLK2 / DCAMKL2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCLK2
Synonyms DCAMKL2, DCDC3B, DCK2
Function Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
Cellular Location Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Tissue Location Expressed in the brain, heart and eyes.
Research Areas
Citations (0)

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Background

Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

References

Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Reiner O.,et al.BMC Genomics 7:188-188(2006).
Tuy F.P.D.,et al.Dev. Neurosci. 30:171-186(2008).

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$ 395.00
Cat# ALS13557
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