|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (2.5-5 µg/ml), WB (1:32000)|
|Other Names||LIM and SH3 domain protein 1, LASP-1, Metastatic lymph node gene 50 protein, MLN 50, LASP1, MLN50|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||LASP1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).|
|Cellular Location||Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F- actin rich cortical cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Tomasetto C.L.,et al.Genomics 28:367-376(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Tomasetto C.,et al.FEBS Lett. 373:245-249(1995).
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