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TPM1 / Tropomyosin Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P09493 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 7168 |
|---|---|
| Other Names | Tropomyosin alpha-1 chain, Alpha-tropomyosin, Tropomyosin-1, TPM1, C15orf13, TMSA |
| Target/Specificity | Human Tropomyosin 1. Predicted cross-reactivity based on amino acid sequence homology: mouse (99%), rat (88%), rabbit (88%), bovine (88%), pig (88%). |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | TPM1 / Tropomyosin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPM1 |
|---|---|
| Synonyms | C15orf13, TMSA |
| Function | Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04692}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P04692} |
| Tissue Location | Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. {ECO:0000269|PubMed:15249230, ECO:0000269|Ref.15} |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
References
Mische S.M.,et al.Biochem. Biophys. Res. Commun. 142:813-818(1987).
Lin C.-S.,et al.Mol. Cell. Biol. 8:160-168(1988).
McLeod A.R.,et al.Mol. Cell. Biol. 8:433-440(1988).
Denz C.R.,et al.Biochem. Biophys. Res. Commun. 320:1291-1297(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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