|Application ||IHC-P, E|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component, GC|
|Target/Specificity||Recognizes Vitamin D binding protein (VDBP), the major carrier protein of vitamin D that also transports components such as fatty acids and endotoxins and has an important role in the actin scavenging system. VDBP is a 52-58 kD plasma protein synthes ...|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||GC / Vitamin D-Binding Protein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|
|Tissue Location||Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine|
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Provided below are standard protocols that you may find useful for product applications.
Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
Cooke N.E.,et al.J. Clin. Invest. 76:2420-2424(1985).
Yang F.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:7994-7998(1985).
Braun A.,et al.Biochim. Biophys. Acta 1216:385-394(1993).
Witke W.F.,et al.Genomics 16:751-754(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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