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OSBPL1A / ORP1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - OSBPL1A / ORP1 Antibody (C-Terminus) ALS13631
    Anti-OSBPL1A / ORP1 antibody IHC of human brain, cerebellum.
  • IHC - OSBPL1A / ORP1 Antibody (C-Terminus) ALS13631
    Anti-OSBPL1A / ORP1 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BXW6
Reactivity Human, Mouse, Rat, Monkey, Pig, Chicken, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 108kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 114876
Other Names Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B
Target/Specificity Human OSBPL1A / ORP1. This antibody is expected to recognise both reported human isoforms of this protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsOSBPL1A / ORP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OSBPL1A
Synonyms ORP1, OSBP8, OSBPL1, OSBPL1B
Function Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).
Cellular Location Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes
Research Areas
Citations (0)

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Background

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A.

References

Jaworski C.J.,et al.Genomics 78:185-196(2001).
Xu Y.,et al.J. Biol. Chem. 276:18407-18414(2001).
Lehto M.,et al.J. Lipid Res. 42:1203-1213(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).

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$ 395.00
Cat# ALS13631
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