|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||ELISA (1:16000), IHC-P (5 µg/ml), WB (0.5-2 µg/ml)|
|Other Names||Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B|
|Target/Specificity||Human OSBPL1A / ORP1. This antibody is expected to recognise both reported human isoforms of this protein.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||OSBPL1A / ORP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ORP1, OSBP8, OSBPL1, OSBPL1B|
|Function||Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).|
|Cellular Location||Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes|
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Provided below are standard protocols that you may find useful for product applications.
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A.
Jaworski C.J.,et al.Genomics 78:185-196(2001).
Xu Y.,et al.J. Biol. Chem. 276:18407-18414(2001).
Lehto M.,et al.J. Lipid Res. 42:1203-1213(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
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