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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP26B1 Antibody   

CYP26B1 Antibody

Rabbit Polyclonal Antibody

     
  • WB - CYP26B1 Antibody ALS13642
    Sample (30 ug of whole cell lysate). A: Hep G2. 7.5% SDS PAGE. CYP26B1 antibody diluted at 1:1000.
  • IHC - CYP26B1 Antibody ALS13642
    Anti-CYP26B1 antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NR63
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 58kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 56603
Other Names Cytochrome P450 26B1, 1.14.-.-, Cytochrome P450 26A2, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, Retinoic acid-metabolizing cytochrome, CYP26B1, CYP26A2, P450RAI2
Target/Specificity Human Cytochrome P450 26B. Predicted cross-reactivity based on amino acid sequence homology: mouse (94%), rat (94%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsCYP26B1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP26B1
Synonyms CYP26A2, P450RAI2
Function Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein
Tissue Location Highly expressed in brain, particularly in the cerebellum and pons.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.

References

White J.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:6403-6408(2000).
Savenstrand H.,et al.Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Laue K.,et al.Am. J. Hum. Genet. 89:595-606(2011).

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$ 395.00
Cat# ALS13642
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