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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GABRB1 Antibody   

GABRB1 Antibody

Rabbit Polyclonal Antibody

     
  • WB - GABRB1 Antibody ALS13643
    Sample(30g whole cell lysate).
  • IHC - GABRB1 Antibody ALS13643
    Anti-GABRB1 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P18505
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 54kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:3000),
Additional Information
Gene ID 2560
Other Names Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABRB1
Target/Specificity Human GABA A Receptor beta 1. Predicted cross-reactivity based on amino acid sequence homology: mouse (89%), rat (89%), bovine (89%), zebrafish (90%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsGABRB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABRB1
Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.
Cellular Location Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P50571}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}
Volume 50 µl
Research Areas
Citations (0)

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Background

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity).

References

Schofield P.R.,et al.FEBS Lett. 244:361-364(1989).
Kirkness E.F.,et al.Genomics 10:985-995(1991).
Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 395.00
Cat# ALS13643
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