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GABRB1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P18505 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54kDa |
| Dilution | IHC-P (10 µg/ml), WB (1:500-1:3000), |
| Gene ID | 2560 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABRB1 |
| Target/Specificity | Human GABA A Receptor beta 1. Predicted cross-reactivity based on amino acid sequence homology: mouse (89%), rat (89%), bovine (89%), zebrafish (90%). |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | GABRB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GABRB1 |
|---|---|
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as a receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as a ligand-gated chloride channel. |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P50571}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571} |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity).
References
Schofield P.R.,et al.FEBS Lett. 244:361-364(1989).
Kirkness E.F.,et al.Genomics 10:985-995(1991).
Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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